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M8-B Hydrochloride
CAS No. 883976-12-3
M8-B Hydrochloride( —— )
Catalog No. M21971 CAS No. 883976-12-3
M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 72 | In Stock |
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| 10MG | 102 | In Stock |
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| 25MG | 222 | In Stock |
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| 50MG | 357 | In Stock |
|
| 100MG | 530 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameM8-B Hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionM8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist.
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DescriptionM8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect.?It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions.?M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures.?M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures.
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In Vitro——
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In VivoAnimal Model:Trpm8+/+ rats and mice Dosage:6 mg/kg Administration:I.v. or i.p.Result:Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8?/? mice.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRPM8
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Research Area——
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Indication——
Chemical Information
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CAS Number883976-12-3
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Formula Weight432.96
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Molecular FormulaC22H25ClN2O3S?
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (577.42 mM)
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SMILESCl.COc1cc(CN(CCN)C(=O)c2cccs2)ccc1OCc1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zandi N , Zaniani N R , Moghimi A , et al. Protective effects of M8?B, a TRPM8 antagonist, on febrile? and pentylenetetrazol?induced seizures[J]. Acta neurobiologiae experimentalis, 2019, 79(1):86-91.
2. Almeida M C , Hew-Butler T , Soriano R N , et al. Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature[J]. Journal of Neuroscience, 2012, 32(6):2086-2099.
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